Learning methods and systems are provided for predictive medical image calibration. In various embodiments, a request is received from a user for an image. One or more characteristic of the image is determined. One or more characteristic of the user is determined. A generalized linear model is applied to the one or more characteristic of the image and the one or more characteristic of the user to determine one or more image transformation. The one or more image transformation is applied to the image. The generalized linear model is updated based on any user-applied image transformations.