A universal serial bus (USB) hub supporting multiple hosts and an automobile head unit using the same are provided. A USB hub circuit is set in the USB hub, which is coupled to external connectors through a bus matrix. Herein, an upstream port connector of the USB hub is coupled to the automobile head unit. When one device is coupled to a downstream port requests to serve as a host, the bus matrix couples the downstream port, coupled to the requesting device, to an upstream port of the USB hub circuit, and couples the downstream port to the automobile head unit to make the automobile head unit serve as the device.