Invention Grant
- Patent Title: Salt and crystal forms of PLK-4 inhibitor
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Application No.: US15886104Application Date: 2018-02-01
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Publication No.: US10392374B2Publication Date: 2019-08-27
- Inventor: Peter Brent Sampson , Miklos Feher , Heinz W. Pauls
- Applicant: University Health Network
- Applicant Address: CA Toronto
- Assignee: University Health Network
- Current Assignee: University Health Network
- Current Assignee Address: CA Toronto
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- Main IPC: C07D413/14
- IPC: C07D413/14

Abstract:
A fumarate salt and a maleate salt of compound (I) represented by the following structural formula, as well as their corresponding pharmaceutical compositions, are disclosed. Particular single crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are characterized by a variety of properties and physical measurements. Methods of preparing specific crystalline forms of 1:1 compound (I) fumarate and 1:1 compound (I) maleate are also disclosed. The present invention also provides methods of treating a subject with a cancer.
Public/Granted literature
- US20180155335A1 SALT AND CRYSTAL FORMS OF PLK-4 INHIBITOR Public/Granted day:2018-06-07
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