Systems and methods for continued runtime authentication of Information Handling System (IHS) applications. In an illustrative, non-limiting embodiment, an IHS may include one or more processors and a memory coupled to the one or more processors, the memory including program instructions stored thereon that, upon execution by the one or more processors, cause the IHS to: receive a command to execute an application; initially verify a plurality of tokens, where a first token is provided by the application, a second token is provided by an application manager, and a third token is provided by a hardware component within the IHS; and execute the application in response the initial verification being successful.