Invention Grant
- Patent Title: Use of antisense oligonucleotides for producing truncated Ig by exon skipping for the treatment of diseases involving B cells
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Application No.: US15777843Application Date: 2016-11-22
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Publication No.: US10398722B2Publication Date: 2019-09-03
- Inventor: Laurent Delpy , Nivine Srour , Michel Cogné
- Applicant: Universite de Limoges , Centre National de la Recherche Scientifique
- Applicant Address: FR Limoges FR Paris
- Assignee: Universite de Limoges,Centre National de la Recherche Scientifique
- Current Assignee: Universite de Limoges,Centre National de la Recherche Scientifique
- Current Assignee Address: FR Limoges FR Paris
- Agency: Morgan, Lewis & Bockius LLP
- Priority: FR1561252 20151123
- International Application: PCT/EP2016/078475 WO 20161122
- International Announcement: WO2017/089359 WO 20170601
- Main IPC: A61K31/713
- IPC: A61K31/713 ; C12N15/113 ; A61K45/06 ; A61P35/04
Abstract:
The present invention concerns a treatment of diseases involving B cells, B lymphocytes or plasmocytes. In particular, it concerns an antisense oligonucleotide or a mixture of antisense oligonucleotides capable of inducing exon skipping at the RNA of the immunoglobulin heavy or light chains, for the use of same in the treatment of diseases involving B cells.
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