A multi-layer multi-leaf collimation system includes at least a first layer of collimation leaves that are vertically offset with respect to a second layer of collimation leaves. A control circuit generates a preliminary radiation treatment plan using a model of a radiation therapy treatment platform using a single-layer multi-leaf collimation system following which the control circuit generates a final radiation treatment plan that takes into account at least a second layer of collimation leaves. The resultant final radiation treatment plan can then be used to administer radiation to a patient using the aforementioned multi-layer multi-leaf collimation system.