The invention concerns a system for refilling a bottle with liquid, which comprises: a first bottle (S) containing liquid, a second bottle (R) to be refilled with the liquid from the first bottle (S), the second bottle being in an inverted position and comprising a pump mounted on the bottle and equipped with a vent orifice that can be open or closed depending on the position of the pump, a filling interface connecting the two bottles, the interface comprising a liquid passage disposed between the two bottles for the transfer of the liquid under pressure from the first bottle (S) to the inverted second bottle (R) via said vent orifice of the pump of the second bottle when open and a gas passage for the evacuation of gas contained in the inverted second bottle (R) to the exterior of the bottle.