Disclosed is a wheel flange drainage channel cleaning device, comprising a frame, lifting cylinders, guide posts, a servo motor, a lifting platform, a bearing seat, a shaft, a bearing, a rotating platform, a sleeve and the like. Four clamping cylinders move synchronously to clamp a wheel, the lifting cylinders may control ascending and descending of the lifting platform, the servo motor may control rotation of the rotating platform, and when the linear motor drives the racks to reciprocate up and down, the brushes swing left and right, so that aluminum scraps blocked in drainage channels beside the central hole and outside the central hole are easily cleaned.