Invention Grant
- Patent Title: Inhibitors of indoleamine-2,3-dioxygenase for the treatment of cancer
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Application No.: US15564146Application Date: 2016-04-01
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Publication No.: US10399932B2Publication Date: 2019-09-03
- Inventor: James Aaron Balog , Emily Charlotte Cherney , Jay A. Markwalder , Steven P. Seitz , Weifang Shan , David K. Williams , Audris Huang , Susheel Jethanand Nara , Saumya Roy , Soodamani Thangavel , Ramesh Kumar Sistla , Srinivas Cheruku , Srinivasan Thangathirupathy , Yadagiri Kanyaboina , Nagalakshmi Pulicharla
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- International Application: PCT/US2016/025544 WO 20160401
- International Announcement: WO2016/161279 WO 20161006
- Main IPC: C07D309/14
- IPC: C07D309/14 ; C07D405/12 ; C07D413/12 ; C07D335/02 ; C07D211/10 ; C07D265/30 ; C07D409/12 ; C07C275/40 ; A61K31/17 ; A61K31/196 ; A61K31/277 ; A61K31/351 ; A61K31/382 ; A61K31/397 ; A61K31/428 ; A61K31/437 ; A61K31/445 ; A61K31/501 ; A61K31/505 ; A61K31/506 ; A61K31/519 ; A61K31/5375 ; A61K31/5377 ; A61K31/538 ; A61K39/395 ; C07C229/42 ; C07C255/58 ; C07D205/04 ; C07D211/14 ; C07D239/47 ; C07D265/36 ; C07D277/64 ; C07D295/155 ; C07D309/04 ; C07D401/12 ; C07D405/14 ; C07D417/12 ; C07D471/04 ; C07D487/04 ; C07D407/12 ; C07D487/08 ; C07D207/08 ; C07D211/08 ; C07D307/22 ; C07C255/57 ; C07C235/38 ; C07C235/56 ; C07C233/81 ; C07C275/42 ; C07D207/12 ; C07D239/34 ; C07D317/46 ; C07D413/14 ; C07D471/08 ; C07C275/30 ; A61K45/06
Abstract:
There are disclosed compounds of formula (I) that modulate or inhibit the enzymatic activity of indoleamine-2,3-dioxygenase (IDO), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders, such as cancer, viral infections and/or inflammatory disorders utilizing the compounds of the invention.
Public/Granted literature
- US20180079712A1 INHIBITORS OF INDOLEAMINE-2,3-DIOXYGENASE FOR THE TREATMENT OF CANCER Public/Granted day:2018-03-22
Information query
