Invention Grant
- Patent Title: Hydroxyalkyl thiadiazole derivatives
-
Application No.: US15764264Application Date: 2016-09-28
-
Publication No.: US10399968B2Publication Date: 2019-09-03
- Inventor: Manoj Kumar Khera , Tarun Mathur , Jitendra A. Sattigeri , Nobuhisa Masuda , Tsuyoshi Soneda , Yoshiko Kagoshima , Toshiyuki Konosu , Tetsuya Suzuki , Makoto Yamaoka , Ryo Itooka
- Applicant: Daiichi Sankyo Company, Limited
- Applicant Address: JP Chuo-ku
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP Chuo-ku
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Priority: IN3119/DEL/2015 20150930
- International Application: PCT/IB2016/055795 WO 20160928
- International Announcement: WO2017/056012 WO 20170406
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61P31/04

Abstract:
Problem to be SolvedThere is a need for a new antibiotic having a novel mechanism of action which exhibit strong antibacterial activity not only against sensitive bacteria but also against resistant bacteria thereof, and at the same time possesses excellent solubility an a safety profile amenable to human use.Solution to the ProblemAs a result of intensive research, the present inventors have found that a compound represented by general formula (I), a stereoisomer, or a pharmaceutically acceptable salt thereof inhibits DNA gyrase GyrB subunit and/or topoisomerase IV ParE subunit possesses excellent solubility and a safety profile for use in humans for the treatment of bacterial infectious diseases.
Public/Granted literature
- US20180327399A1 HYDROXYALKYL THIADIAZOLE DERIVATIVES Public/Granted day:2018-11-15
Information query