Invention Grant
- Patent Title: Tricyclic compounds as inhibitors of mutant IDH enzymes
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Application No.: US15769414Application Date: 2016-10-25
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Publication No.: US10399972B2Publication Date: 2019-09-03
- Inventor: David J. Witter , Tesfaye Biftu , Purakkattle Biju , Stephane L. Bogen , Qingmei Hong , Chunhui Huang , Xianhai Huang , Bing Li , Min K. Park , David L. Sloman
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Yong Zhao; Catherine D. Fitch
- International Application: PCT/US2016/058614 WO 20161025
- International Announcement: WO2017/074914 WO 20170504
- Main IPC: A61K31/551
- IPC: A61K31/551 ; A61K31/4353 ; C07D471/04 ; C07D519/00 ; A61P35/02 ; C07D491/10 ; C07D498/08
Abstract:
The present invention is directed to tricyclic compounds of formula (I), (Ia) or (Ib) which are inhibitors of one or more mutant IDH enzymes. The present invention is also directed to uses of these tricyclic compounds in the potential treatment or prevention of cancers in which one or more mutant IDH enzymes are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such cancers.
Public/Granted literature
- US20180305352A1 NOVEL TRICYCLIC COMPOUNDS AS INHIBITORS OF MUTANT IDH ENZYMES Public/Granted day:2018-10-25
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