Methods, systems, and computer program products for thermal management of buildings using intelligent and autonomous set-point adjustments are provided herein. A method includes capturing a user-selected setting that represents a desired balance between (i) energy usage and (ii) thermal comfort associated with a building; capturing, via a communication link with one or more hardware devices associated with thermal management of the building, one or more items of real-time information pertaining to the thermal management of the building; determining one or more set-point temperatures for the building based on (i) the user-selected setting, (ii) the items of real-time information pertaining to the thermal management of the building, and (iii) one or more constraints; and outputting the set-point temperatures to the hardware devices associated with the thermal management of the building for execution of a thermal management schedule to be carried out in accordance with the set-point temperatures.