Methods, apparatus, systems and articles of manufacture are disclosed to setup single-use equipment/processes. An example disclosed herein includes configuring a control interface via an object-oriented programming interface, the object-oriented programming interface including an object class representative of a single-use component in the single-use process. The example method also includes activating a single-use object in the control interface by detecting all ports associated with the single-use component are connected, and verifying the single-use component.