Aspects of the present disclosure address improved systems and methods for region-aware clustering in integrated circuit (IC) designs. Consistent with some embodiments, the method may include identifying a clustering region for each clock driver included in an IC design based on locations of sinks and blockages, and timing constraints. The CTS tool finds representative locations for each clock driver within their respective clustering regions. Given the representative location for each clock driver, the CTS tool applies point-based clustering to the clock drivers of the IC design to obtain one or more clusters.