Invention Grant
- Patent Title: Method of preparing composite granule comprising low-substituted hydroxypropyl cellulose and rapid release preparation
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Application No.: US13909516Application Date: 2013-06-04
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Publication No.: US10406107B2Publication Date: 2019-09-10
- Inventor: Naosuke Maruyama , Yasuyuki Hirama
- Applicant: Shin-Etsu Chemical Co., Ltd.
- Applicant Address: JP Tokyo
- Assignee: Shin-Etsu Chemical Co., Ltd.
- Current Assignee: Shin-Etsu Chemical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Alston & Bird LLP
- Priority: JP2012-135714 20120615
- Main IPC: A61K9/20
- IPC: A61K9/20 ; A61K31/167 ; A61K31/375 ; A61K9/00 ; A61K47/38

Abstract:
Provided is a base material for dry direct tableting, the material being excellent in a binding property and disintegrability. More specifically, provided is a method of preparing a composite granule comprising at least a step of granulating a second sugar or sugar alcohol while adding thereto an aqueous dispersion comprising at least low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of 5 to 16% by weight, polyvinyl alcohol, a first sugar or sugar alcohol, and water.
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