Invention Grant
- Patent Title: Composition for inhibiting angiogenesis comprising nanoparticle-vitreous body-based protein complex as active ingredient, and use thereof
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Application No.: US15743895Application Date: 2016-07-12
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Publication No.: US10406110B2Publication Date: 2019-09-10
- Inventor: Jeong Hun Kim , Dong Hyun Jo , Tae Geol Lee
- Applicant: SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION , KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
- Applicant Address: KR Seoul KR Daejeon
- Assignee: Seoul National University R & DB Foundation,Korea Research Institute of Standards and Science
- Current Assignee: Seoul National University R & DB Foundation,Korea Research Institute of Standards and Science
- Current Assignee Address: KR Seoul KR Daejeon
- Agency: Vorys, Sater, Seymour and Pease LLP
- Agent Mih Suhn Koh
- Priority: KR10-2015-0099308 20150713
- International Application: PCT/KR2016/007570 WO 20160712
- International Announcement: WO2017/010790 WO 20170119
- Main IPC: A61K9/14
- IPC: A61K9/14 ; A61K9/51 ; A61K47/42 ; A61P27/02 ; B82Y5/00 ; G01N33/15 ; G01N33/68 ; A61K9/50 ; A61K9/16 ; A61K33/00 ; A61K33/24 ; G01N33/50 ; A61K47/69 ; A61P27/00 ; A61K9/00 ; A61K38/38 ; B82Y30/00
Abstract:
Provided is a nanoparticle-vitreous body-based protein complex, and more particularly, to a composition for inhibiting angiogenesis which includes the complex as an active ingredient, and a composition for preventing or treating an angiogenesis-related disease or a retinal disease. When the nanoparticle-vitreous body-based protein complex according to the subject matter is locally injected into the vitreous body, the complex exhibits significantly excellent binding strength with a vascular endothelial growth factor and thus can inhibit angiogenesis, thus being easily used to prepare a therapeutic agent for preventing, alleviating, or treating retinal and choroidal angiogenesis-related diseases.
Public/Granted literature
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