Invention Grant
- Patent Title: Analogs of pridopidine, their preparation and use
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Application No.: US16150977Application Date: 2018-10-03
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Publication No.: US10406145B2Publication Date: 2019-09-10
- Inventor: Malle Schmidt , Malle Päri , Marit Laos , Ants Maasalu , Kalle Kaljuste
- Applicant: PRILENIA NEUROTHERAPEUTICS LTD.
- Applicant Address: IL Herzliya
- Assignee: PRILENIA NEUROTHERAPEUTICS LTD.
- Current Assignee: PRILENIA NEUROTHERAPEUTICS LTD.
- Current Assignee Address: IL Herzliya
- Agency: Peral Cohen Zedek Latzer Baratz LLP
- Agent Mark S. Cohen
- Main IPC: A61K31/451
- IPC: A61K31/451 ; G01N30/88 ; C07D211/24 ; C07D211/52 ; C07D211/42

Abstract:
This invention provides an isolated compound having the structure: or a salt thereof. The invention also provides for a process for preparing 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-4-ol, 1-(3,3-bis(3-(methylsulfonyl)phenyl)propyl)-4-(3-(methylsulfonyl) phenyl)piperidone, 1,4-bis((3-(1-propylpiperidin-4-yl)phenyl)sulfonyl)butane, (3R,4S)-4-(3-(methylsulfonyl)phenyl)-1-propylpiperidin-3-ol, 4-(3-(methylsulfonyl)phenyl)-1-propylpiperidine 1-oxide, 1-(2-methylpentyl)-4-(3-(methylsulfonyl)phenyl)piperidine, 4-(3-(methylsulfinyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine, and 4-(3-(methylsulfonyl)phenyl)-1-propyl-1,2,3,6-tetrahydropyridine.This invention also provides an impurity or a salt thereof for use, as a reference standard to detect trace amounts of the impurity in a pharmaceutical composition comprising pridopidine or a pharmaceutically acceptable salt thereof. This invention further provides a process for producing a pridopidine drug product comprising obtaining a pridopidine drug substance and. mixing the pridopidine drug substance with suitable excipients so as to produce the pridopidine drug product. This invention also provides a process for producing a pridopidine drug product. This invention also provides a process of distributing a pridopidine drug product.
Public/Granted literature
- US20190030016A1 ANALOGS OF PRIDOPIDINE, THEIR PREPARATION AND USE Public/Granted day:2019-01-31
Information query
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