A method of manufacturing a pneumatic tire including forming a green case by cylindrically winding a tire component member which includes at least one layer of a carcass ply. A green tire is shaped by expanding the green case into a toroidal shape with the supply of a fluid into the green case so that the green case adheres to a tread ring arranged radially outside the green case. The green tire is subjected to vulcanization molding within a mold die. During the shaping of the green tire, the fluid is supplied in accordance with a pressure profile which changes in a stepwise manner. The pressure profile is set such that a former stage expansion rate in a former stage is set to slower than a final stage expansion rate in a final stage.