Various methods and systems are provided for electrochemical digestion of organic molecules. In one example, among others, a method includes providing an electrolyte fluid including organic molecules between the electrodes of a reaction vessel and applying a voltage wave shape to the electrodes of the reaction vessel to digest the organic molecules. No separator exists between the electrodes of the reaction vessel. In another example, a system for digesting organic molecules includes a reaction vessel, an electrolyte fluid including the organic molecules, and a power source. The reaction vessel includes a plurality of electrodes where no separator exists between the electrodes. The electrolyte fluid is provided between the plurality of electrodes of the reaction vessel and the power source can applies a voltage wave shape to the electrodes of the reaction vessel to digest the organic molecules.