Invention Grant
- Patent Title: Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections
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Application No.: US16076781Application Date: 2017-03-02
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Publication No.: US10407421B2Publication Date: 2019-09-10
- Inventor: Weiguo Liu , Fa-Xiang Ding , Wanying Sun , Reynalda Keh Dejesus , Haifeng Tang , Xianhai Huang , Jinlong Jiang , Yan Guo , Hongwu Wang
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp
- Current Assignee: Merck Sharp & Dohme Corp
- Current Assignee Address: US NJ Rahway
- Agent Baerbel R. Brown; Catherine D. Fitch
- International Application: PCT/US2017/020303 WO 20170302
- International Announcement: WO2017/155765 WO 20170914
- Main IPC: C07D417/14
- IPC: C07D417/14 ; A61K45/06 ; C07D471/04 ; C07C53/18 ; A61P31/04 ; A61K31/424 ; A61K31/431 ; A61K31/439

Abstract:
The present invention relates to bicyclic aryl monobactam compounds of Formula (I), and pharmaceutically acceptable salts thereof, wherein A1, L, M, W, X, Y, Z, RX and Rz are as defined herein. The present invention also relates to compositions which comprise a bicyclic aryl monobactam compound of the invention or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The invention further relates to methods for treating a bacterial infection comprising administering to the patient a therapeutically effective amount of a compound of the invention, either alone or in combination with a therapeutically effective amount of one or more beta-lactamase inhibitor compounds.
Public/Granted literature
- US20190071436A1 BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS Public/Granted day:2019-03-07
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