• Patent Title: Processes for the preparation of Vemurafenib
  • Application No.: US16313597
    Application Date: 2017-06-30
  • Publication No.: US10407427B2
    Publication Date: 2019-09-10
  • Inventor: Antti Kataja
  • Applicant: Fermion Oy
  • Applicant Address: FI Espoo
  • Assignee: FERMION OY
  • Current Assignee: FERMION OY
  • Current Assignee Address: FI Espoo
  • Agency: Buchanan Ingersoll & Rooney PC
  • Priority: FI20165557 20160701; FI20165778 20161012
  • International Application: PCT/FI2017/000012 WO 20170630
  • International Announcement: WO2018/002415 WO 20180104
  • Main IPC: C07D471/04
  • IPC: C07D471/04
Processes for the preparation of Vemurafenib
Abstract:
Novel processes are disclosed for manufacture of N-(3-(5-(4-chlorophenyl)-l H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (I), wherein no protection-deprotection sequences or halogenation steps are required and use of palladium catalysts is minimized.
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