Invention Grant
- Patent Title: Compositions and methods for treating neoplasia, inflammatory disease and other disorders
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Application No.: US15886559Application Date: 2018-02-01
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Publication No.: US10407441B2Publication Date: 2019-09-10
- Inventor: James Elliott Bradner , Jun Qi
- Applicant: Dana-Farber Cancer Institute, Inc.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Foley Hoag LLP
- Main IPC: A61K31/551
- IPC: A61K31/551 ; A61P35/00 ; C07D495/14 ; C07D487/04 ; C07D495/12 ; C07D519/00 ; A61K31/5517
Abstract:
The invention features compositions and methods for treating or preventing a neoplasia. More specifically, the invention provides compositions and methods for disrupting the interaction of a BET family polypeptide comprising a bromodomain with chromatin (e.g., disrupting a bromodomain interaction with an acetyl-lysine modification present on a histone N-terminal tail).
Public/Granted literature
- US20180237454A1 COMPOSITIONS AND METHODS FOR TREATING NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS Public/Granted day:2018-08-23
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