Invention Grant
- Patent Title: Massive parallel method for decoding DNA and RNA
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Application No.: US16149098Application Date: 2018-10-01
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Publication No.: US10407458B2Publication Date: 2019-09-10
- Inventor: Jingyue Ju , Zengmin Li , John Robert Edwards , Yasuhiro Itagaki
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- Main IPC: C07H19/14
- IPC: C07H19/14 ; C12Q1/68 ; C07H21/00 ; C12Q1/686 ; C12Q1/6874 ; C12Q1/6872 ; C12Q1/6869 ; C07H19/10 ; C12Q1/6876 ; C40B40/00

Abstract:
This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogs which comprise unique labels attached to the nucleotide analog through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.
Public/Granted literature
- US20190031704A1 MASSIVE PARALLEL METHOD FOR DECODING DNA AND RNA Public/Granted day:2019-01-31
Information query
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