This disclosure relates to a cam-type sanitary clamp for releasably coupling two flanged ends of a sanitary fitting, such as a tri-clover fitting. The clamp has an upper clamp ring component hinged to a lower clamp ring component, with a threaded shaft component that is pivotally connected to the lower clamp ring component, a cylindrical pivot component, and a cam-type lever component. The lever is pivotally connected to the pivot component and has a plurality of protrusions, such as lobes, that are each configured to be compressed against the slotted opening of the upper clamp ring section when the cam-type lever component is manually rotated from an open position to a closed position to secure the clamp about the flanges of a sanitary fitting.