Embodiments of active noise control (ANC) headphones and operating methods thereof are disclosed herein. In one example, a headphone for ANC includes a speaker, a microphone, an echo-cancel module, and an ANC module. The speaker is configured to play an audio based on a first audio source signal. The microphone is configured to obtain a mixed audio signal including a noise signal and a second audio source signal based on the audio played by the speaker. The echo-cancel module is configured to reduce the second audio source signal from the mixed audio signal based on the first audio source signal to generate an echo-cancel audio signal. The ANC module is operatively coupled to the echo-cancel module and configure to generate a noise-controlled audio source signal to be played by the speaker based on the echo-cancel audio signal and the first audio source signal.