Disclosed systems, methods, and computer program products enable high symbol-rate optical Nyquist signal generation with roll-off factors approaching zero by combining digital and all-optical methods. The combined digital and all-optical methods utilize all-optical sine-shaped pulse generation and orthogonal time-division multiplexing with quadrature amplitude modulation using digital Nyquist signals. Disclosed embodiments exhibit inter-channel-interference penalties that are less than 0.5-dB for both 75-GBaud and 125-GBaud optical Nyquist signals, in contrast to conventional signals generated using rectangular waveform driving signals that exhibit penalties greater than 2.5-dB and 1.5-dB for 75-GBaud and 125-GBaud signals, respectively. The disclosed embodiments, therefore, enable significant improvement over conventional systems by reducing inter-channel-interference penalties caused by excess modulation induced bandwidth.