Invention Grant
- Patent Title: Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders using an inhibitor of Akt kinase
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Application No.: US15950965Application Date: 2018-04-11
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Publication No.: US10413542B2Publication Date: 2019-09-17
- Inventor: Remi-Martin Laberge , Nathaniel David , Alain Philippe Vasserot , Darren J. Baker , Bennett G. Childs , James L. Kirkland , Tamar Tchkonia , Jan M. A. van Deursen , Yi Zhu
- Applicant: Buck Institute for Research on Aging , Unity Biotechnology, Inc. , Mayo Foundation for Medical Education and Research
- Applicant Address: US CA Novato US CA Brisbane US MN Rochester
- Assignee: Buck Institute for Research on Aging,Unity Biotechnology, Inc.,Mayo Foundation for Medical Education and Research
- Current Assignee: Buck Institute for Research on Aging,Unity Biotechnology, Inc.,Mayo Foundation for Medical Education and Research
- Current Assignee Address: US CA Novato US CA Brisbane US MN Rochester
- Agency: Wilson, Sonsini, Goodrich & Rosati
- Agent Michael Schiff; Janet Martineau
- Main IPC: A61K31/4375
- IPC: A61K31/4375 ; A61P11/00 ; A61P9/10 ; A61P19/02 ; A61K31/496 ; A61P27/02 ; A61K31/428 ; A61K31/495 ; A61K31/5377 ; A61K31/404 ; A61K45/06 ; A61K31/4178 ; A61K31/728 ; C12N5/00 ; A61K47/36 ; A61K9/00 ; C12Q1/48
Abstract:
Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases and disorders; and senescence-associated dermatological diseases and disorders.
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