Embodiments of the invention are directed to methods for handling cache prefetch requests. The method includes receiving a request to prefetch data from main memory to a cache. The method further includes based on a determination that the prefetch request is a speculative prefetch request, determining if the cache is being used for transactional memory. The method further includes based on a determination that the cache is not being used for transactional memory, processing the prefetch request. The method further includes based on a determination that the cache is being used for transactional memory, and a determination if the prefetch request can be processed without affecting transactional memory, processing the prefetch request. The method further includes based on a determination that the cache is being used for transactional memory, and a determination if the prefetch request can be processed without affecting transactional memory, rejecting the prefetch request.