A system and method is disclosed for monitoring the containment of an epidemic in relation to a location-based restriction using an anonymized database of spending records. The system measures the effectiveness of a restriction by analyzing the spending records of individuals in the population and identifies transaction trends that relate to the restriction and correlates them to the effectiveness of the restriction. Based on the identified transaction trends, the system calculates the effectiveness and analyzes the restrictions according to expected trends and models of epidemic spread by geography. The system utilizes the measured effectiveness and predictive analysis to generate notifications if the effectiveness does not meet prescribed requirements and to recommend corrective action. In addition, the system can dynamically update restrictions, implement new restrictions and in certain embodiments, the system can elicit (and respond to) actions that are taken at remote devices, such as mobile phones, computers and POS terminals.