Invention Grant
- Patent Title: Pancreatic cancer therapy and diagnosis
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Application No.: US15304598Application Date: 2015-04-17
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Publication No.: US10420757B2Publication Date: 2019-09-24
- Inventor: Pouria Jandaghi , Jörg Hoheisel , Yasser Riazalhosseini
- Applicant: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts , The Royal Institution for the Advancement of Learning/McGill University
- Applicant Address: DE Heidelberg CA Montreal
- Assignee: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts,The Royal Institution for the Advancement of Learning/McGill University
- Current Assignee: Deutsches Krebsforschungszentrum Stiftung des Öffentlichenrechts,The Royal Institution for the Advancement of Learning/McGill University
- Current Assignee Address: DE Heidelberg CA Montreal
- Agency: Norton Rose Fulbright US LLP
- Priority: EP14165053 20140417
- International Application: PCT/EP2015/058380 WO 20150417
- International Announcement: WO2015/158890 WO 20151022
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61K31/454 ; A61K31/7068

Abstract:
The current disclosure relates to methods for treating pancreatic cancer or chronic pancreatitis in a subject comprising administering an antagonist of a dopamine receptor to the subject wherein the dopamine receptor is, in some specific cases dopamine receptor D2 (DRD2). The antagonist in some specific cases is an RNAi construct, an antibody, or a small molecule and in more specific cases pimozide or L-741,626. The disclosure also relates to diagnostic methods comprising the detection of the expression of DRD2 in pancreatic tissue and kits for doing the same.
Public/Granted literature
- US20170035746A1 Pancreatic Cancer Therapy and Diagnosis Public/Granted day:2017-02-09
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