Invention Grant
- Patent Title: Allosteric inhibitors of thymidylate synthase
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Application No.: US14773906Application Date: 2014-03-17
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Publication No.: US10420761B2Publication Date: 2019-09-24
- Inventor: Maria Zajac-Kaye , Lidia Kulemina
- Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Applicant Address: US FL Gainesville
- Assignee: University of Florida Research Foundation, Inc.
- Current Assignee: University of Florida Research Foundation, Inc.
- Current Assignee Address: US FL Gainesville
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2014/030143 WO 20140317
- International Announcement: WO2014/145386 WO 20140918
- Main IPC: A61K31/505
- IPC: A61K31/505 ; A61K31/472 ; A61K31/137 ; A61K31/352 ; A61K31/404 ; A61K31/4196 ; A61K31/429 ; A61K31/44 ; A61K31/4468 ; A61K31/451 ; A61K31/4709 ; A61K31/4745 ; A61K31/496 ; A61K31/515 ; A61K31/519 ; A61K31/575 ; A61K31/708 ; A61K31/4439 ; A61K31/454 ; A61K31/48 ; A61K31/522 ; A61K31/573 ; A61K31/7072 ; A61K31/7076 ; A61K45/06 ; C07D213/77 ; C07D217/20 ; C07D239/48 ; C07D405/12

Abstract:
The current invention is directed to a class of compounds that inhibit the function of Thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells. Thymidylate synthase inhibition is, thus, useful for treatment of various types of cancers, including but not limited to, acute lymphoblatic leukemia (ALL), acute myelogenous leukemia (AML), acute promyelocytic leukemia, chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute monocytic leukemia (AMOL), hairy cell leukemia, large cell immunoblastic lymphoma, plasmacytoma, multiple myeloma, Hodgkin's lymphoma, non-Hodgkin's lymphoma, leukemia, brain cancer, lung cancer, central nervous system (CNS) cancer, melanoma, renal cancer, prostate cancer, colon cancer, ovarian cancer and breast cancer. The compounds disclosed herein can be used alone or in combination with other cancer treatment regimens (e.g., radiation therapy and/or other chemotherapeutic agents that are administered to a subject having a tumor, cancer or neoplasia).
Public/Granted literature
- US20160067240A1 NOVEL ALLOSTERIC INHIBITORS OF THYMIDYLATE SYNTHASE Public/Granted day:2016-03-10
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