Invention Grant
- Patent Title: Pyrrolobenzodiazepines and conjugates thereof
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Application No.: US15510345Application Date: 2015-09-11
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Publication No.: US10420777B2Publication Date: 2019-09-24
- Inventor: Philip Wilson Howard , Stephen John Gregson , Jean-Noel Levy
- Applicant: MEDIMMUNE LIMITED
- Agency: Casimir Jones, S.C.
- Agent Melissa E. Kolom
- Priority: GB1416112.9 20140912
- International Application: PCT/GB2015/052629 WO 20150911
- International Announcement: WO2016/038383 WO 20160317
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K31/5517 ; C07D487/04 ; C07K5/062 ; C07K5/065 ; C07K5/078 ; A61K47/68 ; C07K16/30

Abstract:
A conjugate comprising a PBD dimer linked from the tether joining the two PBD units, wherein the linker is of formula (A1):(Formula (A1)) wherein RN1 is selected from H and C1-4 alkyl; L is a linker connected to a cell binding agent; CBA is the cell binding agent; n is an integer selected in the range of 0 to 48; Q is: (Formula (Q)), where Qx is such that Q is an amino-acid residue, a dipeptide residue or a tripeptide residue.
Public/Granted literature
- US20170239365A1 PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF Public/Granted day:2017-08-24
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