Invention Grant
- Patent Title: Isolation and use of human lymphoid organ-derived suppressive stromal cells
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Application No.: US14386535Application Date: 2013-03-13
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Publication No.: US10420801B2Publication Date: 2019-09-24
- Inventor: Anne Fletcher , Shannon J. Turley , Biju Parekkadan
- Applicant: Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
- Applicant Address: US MA Boston US MA Boston
- Assignee: The General Hospital Corporation,Dana-Farber Cancer Institute, Inc.
- Current Assignee: The General Hospital Corporation,Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2013/030802 WO 20130313
- International Announcement: WO2013/142186 WO 20130926
- Main IPC: A61K35/26
- IPC: A61K35/26 ; C12N5/078 ; C12N5/077 ; A61K38/18 ; A61K38/19 ; A61K38/20 ; A61K35/12
Abstract:
A method for suppressing an immune response is provided. The method involves administration of isolated lymphoid tissue-derived suppressive stromal cells (LSSC) to a subject in need of such treatment in an amount effective to suppress the immune response in the subject. The invention also involves a method to isolate LSSC by digesting lymphoid tissue fragments using a combination of an enzyme mix and agitation and then collecting the LSSC. Pharmaceutical preparations comprising LSSC are also provided.
Public/Granted literature
- US20150050298A1 ISOLATION AND USE OF HUMAN LYMPHOID ORGAN-DERIVED SUPPRESSIVE STROMAL CELLS Public/Granted day:2015-02-19
Information query
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