The present invention relates to a wire harness arrangement structure of a vehicle, comprising plural component control parts to control plural electric components for governing a drive of the vehicle, a main control part to generate a command signal for providing a command to the plural component control parts, and plural main wire harnesses to transmit the command signal to the plural component control parts. The plural electric components include at least a brake, an engine, a transmission, and a steering, the plural main wire harnesses comprise first signal transmission routes which extend from the main control part to the plural component control parts, respectively, and second signal transmission routes which extend from the main control part to the plural component control parts, respectively, and the command signal is transmitted to the main control part to the plural component control parts through the first and second signal transmission routes.