Invention Grant
- Patent Title: EBNA1 inhibitors and their method of use
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Application No.: US15814600Application Date: 2017-11-16
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Publication No.: US10421718B2Publication Date: 2019-09-24
- Inventor: Troy E. Messick , Garry R. Smith , Allen B. Reitz , Paul M. Lieberman , Mark E. McDonnell , Yan Zhang , Venkata Velvadapu
- Applicant: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- Applicant Address: US PA Philadelphia
- Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- Current Assignee: THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
- Current Assignee Address: US PA Philadelphia
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Domingos J. Silva
- Main IPC: A61K31/195
- IPC: A61K31/195 ; A61K31/405 ; A61K31/41 ; A61K31/42 ; A61K31/415 ; A61K31/40 ; C07D207/327 ; A61K31/404 ; A61K31/4439 ; A61K31/496 ; A61K31/192 ; A61K31/44 ; C07C229/56 ; C07C255/54 ; C07C255/55 ; C07C211/27 ; C07C217/84 ; C07C233/11 ; C07C233/64 ; C07C233/65 ; C07C235/58 ; C07C311/08 ; C07C311/16 ; C07C311/17 ; C07C317/14 ; C07D235/06 ; C07D403/10 ; C07D239/26 ; C07D409/10 ; C07D417/10 ; C07D471/04 ; C07D487/04 ; C07D209/08 ; C07D295/155 ; C07D213/55 ; C07C53/18 ; C07C63/66 ; C07C65/19 ; C07C65/28 ; C07C229/64 ; C07C317/44 ; C07D207/08 ; C07D207/12 ; C07D207/14 ; C07D207/16 ; C07D211/70 ; C07D213/64 ; C07D213/74 ; C07D215/14 ; C07D231/12 ; C07D249/06 ; C07D277/30 ; C07D307/79 ; C07D333/54 ; C07D401/04 ; C07D401/10
Abstract:
Pharmaceutical compositions of the invention comprise EBNA1 inhibitors useful for the treatment of diseases caused by EBNA1 activity such as cancer, infectious mononucleosis, chronic fatigue syndrome, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by latent Epstein-Barr Virus (EBV) infection. Pharmaceutical compositions of the invention also comprise EBNA1 inhibitors useful for the treatment of diseases caused by lytic Epstein-Barr Virus (EBV) infection.
Public/Granted literature
- US20180086699A1 EBNA1 INHIBITORS AND THEIR METHOD OF USE Public/Granted day:2018-03-29
Information query
