System and method to produce an anonymized cohort, members of the cohort having less than a predetermined risk of re-identification. The method includes receiving a data query of requested traits to request in an anonymized cohort, querying a data source to find records that possess at least some of the traits, forming a dataset from at least some of the records, and calculating an anonymity histogram of the dataset. For each patient record within the dataset, the method anonymizes the dataset by calculating using a threshold selector whether a predetermined patient profile within the dataset should be perturbed, calculating using a value selector whether a value within the indicated patient profile should be perturbed, and suppressing an indicated value within the indicated patient profile. The anonymized dataset then is returned.