Securing system for wheelchairs in vehicles, comprising a rigid bottom frame provided with; —a number of fixation elements which are connected to the if bottom frame and suitable for fixing a wheelchair relative to the bottom frame, wherein each fixation elements comprises a coupling element configured for coupling to a wheelchair, which coupling element is connected with a cable to a retractor, which retractor in unlocked mode exerts a retracting pulling force on the coupling element while the cable can be pulled out, and in locked mode locks the cable so that it cannot be pulled out, wherein the retractors are fixedly connected to the bottom frame and are preferably placed adjacently of each other, and a central securing control for simultaneous operation of the retractors.