- Patent Title: Methods of treating cancer having an active Wnt/β-catenin pathway
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Application No.: US14389310Application Date: 2013-03-13
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Publication No.: US10426774B2Publication Date: 2019-10-01
- Inventor: William C. Hahn , Joseph Rosenbluh
- Applicant: DANA-FARBER CANCER INSTITUTE, INC.
- Applicant Address: US MA Boston
- Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee: Dana-Farber Cancer Institute, Inc.
- Current Assignee Address: US MA Boston
- Agency: Cooley LLP
- Agent Cynthia Kozakiewicz; Ivor R. Elrifi
- International Application: PCT/US2013/030889 WO 20130313
- International Announcement: WO2013/148198 WO 20131003
- Main IPC: A61K31/506
- IPC: A61K31/506 ; G01N33/50 ; A61K45/06 ; C07K14/47 ; C12N15/113
Abstract:
The present invention provides methods of treating a subject having a Wnt/beta-catenin active cancer by administering to said subject a compound that inhibits the expression or activity of YES1, BIRC5 or BCL2L1, a compound that inhibits YAP1-beta-catenin complex formation, a compound that inhibits YAP1-beta-catenin complex binding to DNA, a compound that inhibits YAP1-beta-catenin-TBX5 complex formation, or any combination thereof. The compound can be, for example, a nucleic acid, a peptide, an antibody or a small molecule. Methods of screening for therapeutic targets for treating cancer are included.
Public/Granted literature
- US20150065518A1 METHODS OF TREATING CANCER HAVING AN ACTIVE WNT/BETA-CATENIN PATHWAY Public/Granted day:2015-03-05
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