The present disclosure pertains to a pressure support system configured to adjust a pressurized flow of breathable gas delivered to a subject. The system is configured to simplify adjustments to humidity and/or temperature control and/or pressure support therapy that enhance the comfort level of the subject during therapy. The system is configured to generate output signals and/or determine various parameters related to the pressurized flow of breathable gas. The system is configured to receive feedback from the subject related to a comfort level of the subject during therapy and automatically adjust the pressurized flow of breathable gas and/or the predetermined therapy regime, provide feedback to the subject, and/or prompt the subject to make manual adjustments based on the output signals, the determined parameters, the feedback, and/or other information.