A pipe clamp includes two clamp parts, each clamp part having a curved pipe clamping portion, and an anchoring portion formed at or near a first end of each pipe clamping portion to anchor the pipe clamp to a profile element. The anchoring portion is formed as a leg with a hammerhead. A flange is formed at a second end of each pipe clamping portion. The flanges of the clamp parts are adapted to be positioned opposite each other. A tightening member is associated with the clamp flanges for tightening them together. The curved pipe clamping portion has a varying stiffness along the curve length between the first end and the second end of the pipe clamping portion, where on average the stiffness of the pipe clamping portion decreases or increases from the first end towards the second end.