In accordance with embodiments of the present disclosure, a system may include a plurality of slots each configured to receive a modular information handling system, a plurality of air movers each configured to cool at least one modular information handling system disposed in at least one of the plurality of slots, and a controller communicatively coupled to the plurality of slots and the plurality of air movers and configured to, based on one or more thermal operational parameters associated with the plurality of slots and the plurality of air movers, determine an optimal allocation of at least one workload to a particular information handling system of a plurality of modular information handling systems received in the plurality of slots.