The present disclosure discloses a pixel driving structure, a display panel and a display device. The structure includes a pixel combination formed by a first pixel unit and a second pixel unit, a scan line, a data line, a gate driver and a source driver. The first pixel unit of the odd row pixel combination is connected to one odd row scan line, the second pixel unit of the odd row pixel combination is connected to the next even row scan line of the odd row scan line; the first pixel unit of the even row pixel combination is connected to the next two even row scan lines of the odd row scan line, the second pixel unit is connected to the next odd row scan line of the odd line scan line, the first pixel unit and the second pixel unit are connected to the same data line.