Invention Grant
- Patent Title: Methods to identify amino acid residues involved in macromolecular binding and uses therefor
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Application No.: US14419229Application Date: 2013-08-02
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Publication No.: US10431325B2Publication Date: 2019-10-01
- Inventor: Neeraj J. Agrawal , Bernhard Helk , Bernhardt L. Trout
- Applicant: Novartis AG , Massachusetts Institute of Technology (MIT)
- Applicant Address: CH Basel US MA Cambridge
- Assignee: NOVARTIS AG,MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)
- Current Assignee: NOVARTIS AG,MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT)
- Current Assignee Address: CH Basel US MA Cambridge
- Agency: Morrison and Foerster LLP
- International Application: PCT/US2013/053499 WO 20130802
- International Announcement: WO2014/022817 WO 20140206
- Main IPC: G16B15/00
- IPC: G16B15/00 ; G16B35/00 ; G16B5/00 ; G16C20/60 ; C07K1/107
Abstract:
The present disclosure relates to methods and computational tools based, at least in part, on computer simulations that identify hot-spot amino acid residues and binding-region amino acid residues of a protein.
Public/Granted literature
- US20150205912A1 METHODS TO IDENTIFY AMINO ACID RESIDUES INVOLVED IN MACROMOLECULAR BINDING AND USES THEREFOR Public/Granted day:2015-07-23
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