An operation method of an in-band full duplex (IFD) multiple-input multiple-output (MIMO) transceiver, including a reception part, a transmission part, an analog self-interference (SI) generator, and a self-interference cancellation (SIC) controller, may comprise generating, at the SIC controller, a control signal for analog SIC and digital SIC and outputting the control signal to the reception part and the analog SI generator; cancelling, at the SIC controller, SI of a transmission signal of the transmission part based on the control signal; and cancelling, at the reception part, SI of a signal of the reception part based on the control signal.