In accordance with an embodiment, described herein is a system and method useful in enterprise deployment, for enabling application-to-application communication in an enterprise computer system, for example a middleware machine. The system can include a plurality of application hosts and managed servers which receive requests at an external load balancer, via an Ethernet over InfiniBand (EoIB) network, together with a plurality of web hosts and traffic directors. Each traffic director instance can be associated with a virtual Internet Protocol (VIP) address that is accessible via a high-speed internal InfiniBand (IB) network. Hosted applications within the enterprise computer system can communicate with each other, over the IB network, using a VIP address. Such application-to-application wiring avoids the need to communicate internal application requests via the external load balancer.