Embodiments of the present application enable setup synchronization of an end user medical device (110) such as a blood glucose meter. The invention includes a controller (302) including a memory (304); a transceiver (306) operatively coupled to the controller; and a host computer (104) interface (208) operative to couple the controller to a host computer, wherein the memory is operative to store instructions executable on the controller. The instructions are adapted to cause the controller to scan for an advertising medical device using the transceiver, establish a communications connection with a medical device advertising for synchronization, and transmit synchronization data to a medical device once a communication connection has been established. Numerous other aspects are disclosed.