The present application discloses a personal vaporizer system with an e-liquid reservoir isolated from the atomizer. The isolation of the e-liquid reservoir from the atomizer eliminates particles contamination of the e-liquid held in the reservoir and chemical reactions between the atomizer and the e-liquid. Since the residence time of “fresh” e-liquid in the atomizer is only the necessary to vaporize a very small amount of e-liquid, particles contamination of the produced vapor and chemical reactions between the e-liquid and atomizer components are dramatically reduced. This represents a huge health benefit for the consumer, compared to all others personal vaporizers with an e-liquid reservoir. The disclosed system can be used in any type of personal vaporizer, for example in the electronic cigarette market.