A medical imaging system for determining a scan orientation is provided. The system comprises: a computing device; a display device; an input device; and, an imaging device, the computing device configured to: instruct the imaging device to acquire at least a sagittal scout scan, an axial scout scan and a coronal scout scan, based on an initial frame of reference; render, at the display device: a two-dimensional representation of each of the scout scans and initial respective selections of a portion of each of the scout scans, oriented according to the initial frame of reference; receive, from the input device, a respective reorientation of one or more of the initial respective selections; transform the initial frame of reference using the respective to produce a reoriented frame of reference; and, instruct the imaging device to acquire further images based on the reoriented frame of reference.