Enhanced targeting systems and methods may be used to visualize trajectories for surgical instruments. Such a targeting system may have a first light source and a second light source. The first light source may project first light along a first plane, and the second light source may project second light along a second plane nonparallel to the first plane. At an intersection of the first and second planes, the first light and the second light may cooperate to produce a targeting line that indicates the desired trajectory. An image capture system may also be used to capture image data of anatomical features of a patient at one or more locations in space, and a controller may receive the image data and indicate the trajectory relative to the anatomical features of the patient.