Invention Grant
- Patent Title: Methods for treatment of bile acid-related disorders and prediction of clinical sensitivity to treatment of bile acid-related disorders
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Application No.: US15524896Application Date: 2015-11-06
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Publication No.: US10434144B2Publication Date: 2019-10-08
- Inventor: Alexander Mark Depaoli , Jian Luo , Hui Tian
- Applicant: NGM Biopharmaceuticals, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- International Application: PCT/US2015/059474 WO 20151106
- International Announcement: WO2016/073855 WO 20160512
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K38/18 ; G01N33/68 ; G01N33/92 ; A61P1/00 ; G01N33/50
Abstract:
Provided herein are methods of using 7a-hydroxy-4-cholsten-3-one (C4) in predicting the clinical sensitivity to treatment of bile acid-related and associated disorders with treatment peptides, such as variants of fibroblast growth factor 19 (FGF19) proteins and peptide sequences (and peptidomimetics) and fusions of FGF19 and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), and variants of fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics).
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